.. User Manual - bossdevice research documentation master file, created by sphinx-quickstart on Fri Jul 9 21:52:50 2021. You can adapt this file completely to your liking, but it should at least contain the root `toctree` directive. .. toctree:: :numbered: :hidden: 1_Home 2_DownloadAndSetup 3_StartBESTToolboxApplication 4_DesignExperiment 5_HardwareConfiguration 6_MEPHotspotSearch 7_MEPThresholdHunting 8_MEPDoseResponseCurve 9_MEPMeasurement 10_rsEEGMeasurement 11_TEPMeasurement 12_rTMSIntervention 13_TUSIntervention 14_TMSfMRIMeasurement 14_ERPMeasurement 15_SensoryThresholdHunting 15_IssuesBugsRequests 16_Workshops 17_About Us ============================================ Introduction to BEST Toolbox ============================================ To facilitate objectivity, reliability, and reproducibility of non-invasive brain stimulation (NIBS) studies and to empower students, researchers, and clinicians alike to conduct state-of-the-art multimodal NIBS studies, an automated but yet flexible tool for data collection and analysis is needed. **B**\rain **E**\lectrophysiological recording and **ST**\imulation (**BEST**\) Toolbox is an easy-to-use MATLAB-based open-source software with a powerful graphical user interface (GUI), which allows the user to flexibly design, run, analyze, and share multi-protocol/multi-session NIBS studies, involving transcranial magnetic, electric, and ultrasound stimulation (TMS, tES, TUS) in combination with EMG, EEG, and fMRI. The BEST toolbox interfaces with a large variety of recording and stimulation devices to analyze data and set stimulation parameters on-the-fly, thereby enabling closed-loop protocols and real-time applications. Its growing functionality includes e.g., TMS motor hotspot search, automated motor threshold estimation, measurement of motor evoked potentials (MEP) and TMS-evoked EEG potentials (TEP), dose-response curves, paired-pulse and dual-coil TMS, rTMS interventions, real-time EEG-triggered stimulation, concurrent TMS-fMRI, etc. Hardware Interfaces ============================================= BEST Toolbox is currently optimized for bossdevice firmware relase 2017b |sync2brain| , a data processing and control system implemented as Simulink© Real-Time model on a high performance computer system receiving a digital real-time data stream from an EEG system such such as: * NeurOne TESLA (Bittium, FL) * actiCHamp Plus (BrainProducts, DE) * CED 1400 (Power and Micro, currently only for EMG modality) Additionaly a native implementation of following buffers is also part of the toolbox. * FieldTrip Real-Time Buffer You may consult developers of BEST Toolbox at github discussions forum for questions specific hardware interfaces. Input Devices --------------------------------------------- The bossdevice firmware release 2017b and FieldTrip real-time buffer in turn allows the BEST Toolbox to interface with a wide variety of hardware and streaming platforms. Including but not limited to followings: * Java * Python * Arduino * BCI2000 includes the FieldTripBuffer and the FieldTripBufferSource modules * BrainVision * NeurOne TESLA * BrainStream * ANT NeuroSDK * Artinis Medical Systems (NIRS) * BrainVision Recorder * Biosemi * CTF (MEG) * Emotiv * Neuromag/Elekta (MEG) * Jinga-Hi (LFP/EEG) * Micromed (ECoG) * ModularEEG/OpenEEG * Neuralynx (LFP) * Neurosky ThinkCap * OpenBCI * TMSI * TOBI The details about implementation of FieldTrip real-time buffer can be found |fieldtrip_buffer| Output Devices ---------------------------------------------- BEST Toolbox is integrated with |MAGIC toolbox| and |neuroFUS open source APIs| in order to control and interact directly with the TMS devices that accepts TTL input for triggering and features API to set the device parameters: * MagVenture (TMS) * MagStim (TMS) * BiStim (TMS) * Rapid (TMS) * DuoMag (TMS) * neuroFUS (TUS) In addition, it can also trigger any stimulation devices that can receive a TTL input trigger. .. |sync2brain| raw:: html sync2brain. .. |fieldtrip_buffer| raw:: html here. .. |MAGIC toolbox| raw:: html MAGIC toolbox .. |neuroFUS open source APIs| raw:: html neuroFUS open source APIs